[Potential antiviral therapeutics for 2019 Novel Coronavirus].
Identifieur interne : 000048 ( Main/Exploration ); précédent : 000047; suivant : 000049[Potential antiviral therapeutics for 2019 Novel Coronavirus].
Auteurs : H. Li [République populaire de Chine] ; Y M Wang [République populaire de Chine] ; J Y Xu [République populaire de Chine] ; B. Cao [République populaire de Chine]Source :
- Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases [ 1001-0939 ] ; 2020.
Descripteurs français
- KwdFr :
- Anticorps monoclonaux (usage thérapeutique), Antiviraux (usage thérapeutique), Chine, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Infections à coronavirus (traitement médicamenteux), Inhibiteurs du cytochrome P-450 CYP3A (usage thérapeutique), Interféron bêta, Lopinavir (usage thérapeutique), Pneumopathie virale (traitement médicamenteux), Ritonavir (usage thérapeutique), Syndrome respiratoire aigu sévère (traitement médicamenteux).
- MESH :
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale, Syndrome respiratoire aigu sévère.
- usage thérapeutique : Anticorps monoclonaux, Antiviraux, Inhibiteurs du cytochrome P-450 CYP3A, Lopinavir, Ritonavir.
- Chine, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Interféron bêta.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Antibodies, Monoclonal (therapeutic use), Antiviral Agents (therapeutic use), Betacoronavirus (drug effects), China, Coronavirus Infections (drug therapy), Cytochrome P-450 CYP3A Inhibitors (therapeutic use), Humans, Interferon-beta, Lopinavir (therapeutic use), Middle East Respiratory Syndrome Coronavirus, Pneumonia, Viral (drug therapy), Ritonavir (therapeutic use), Severe Acute Respiratory Syndrome (drug therapy).
- MESH :
- chemical , therapeutic use : Antibodies, Monoclonal, Antiviral Agents, Cytochrome P-450 CYP3A Inhibitors, Lopinavir, Ritonavir.
- geographic : China, Interferon-beta.
- drug effects : Betacoronavirus.
- drug therapy : Coronavirus Infections, Pneumonia, Viral, Severe Acute Respiratory Syndrome.
- Humans, Middle East Respiratory Syndrome Coronavirus.
Abstract
The recent outbreak of respiratory illness in Wuhan, China is caused by a novel coronavirus, named 2019-nCoV, which is genetically close to a bat-derived coronavirus. 2019-nCoV is categorized as beta genus coronavirus, same as the two other strains-severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Antiviral drugs commonly used in clinical practice, including neuraminidase inhibitors (oseltamivir, paramivir, zanamivir, etc.), ganciclovir, acyclovir and ribavirin, are invalid for 2019-nCoV and not recommended. Drugs are possibly effective for 2019-nCoV include: remdesivir, lopinavir/ritonavir, lopinavir/ritonavir combined with interferon-β, convalescent plasma, and monoclonal antibodies. But the efficacy and safety of these drugs for 2019-nCoV pneumonia patients need to be assessed by further clinical trials.
DOI: 10.3760/cma.j.issn.1001-0939.2020.03.004
PubMed: 32164080
Affiliations:
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Le document en format XML
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Li</name><affiliation wicri:level="1"><nlm:affiliation>Center of Respiratory Medicine, China-Japan Friendship Hospital; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing 100020, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Respiratory Medicine, China-Japan Friendship Hospital; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing 100020</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Y M" sort="Wang, Y M" uniqKey="Wang Y" first="Y M" last="Wang">Y M Wang</name><affiliation wicri:level="1"><nlm:affiliation>Center of Respiratory Medicine, China-Japan Friendship Hospital; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing 100020, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Respiratory Medicine, China-Japan Friendship Hospital; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing 100020</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xu, J Y" sort="Xu, J Y" uniqKey="Xu J" first="J Y" last="Xu">J Y Xu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing 100084, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing 100084</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cao, B" sort="Cao, B" uniqKey="Cao B" first="B" last="Cao">B. Cao</name><affiliation wicri:level="1"><nlm:affiliation>Center of Respiratory Medicine, China-Japan Friendship Hospital; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing 100020, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Respiratory Medicine, China-Japan Friendship Hospital; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing 100020</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases</title><idno type="ISSN">1001-0939</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal (therapeutic use)</term><term>Antiviral Agents (therapeutic use)</term><term>Betacoronavirus (drug effects)</term><term>China</term><term>Coronavirus Infections (drug therapy)</term><term>Cytochrome P-450 CYP3A Inhibitors (therapeutic use)</term><term>Humans</term><term>Interferon-beta</term><term>Lopinavir (therapeutic use)</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Pneumonia, Viral (drug therapy)</term><term>Ritonavir (therapeutic use)</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps monoclonaux (usage thérapeutique)</term><term>Antiviraux (usage thérapeutique)</term><term>Chine</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Inhibiteurs du cytochrome P-450 CYP3A (usage thérapeutique)</term><term>Interféron bêta</term><term>Lopinavir (usage thérapeutique)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Ritonavir (usage thérapeutique)</term><term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antiviral Agents</term><term>Cytochrome P-450 CYP3A Inhibitors</term><term>Lopinavir</term><term>Ritonavir</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term><term>Interferon-beta</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Antiviraux</term><term>Inhibiteurs du cytochrome P-450 CYP3A</term><term>Lopinavir</term><term>Ritonavir</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Chine</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Interféron bêta</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The recent outbreak of respiratory illness in Wuhan, China is caused by a novel coronavirus, named 2019-nCoV, which is genetically close to a bat-derived coronavirus. 2019-nCoV is categorized as beta genus coronavirus, same as the two other strains-severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Antiviral drugs commonly used in clinical practice, including neuraminidase inhibitors (oseltamivir, paramivir, zanamivir, etc.), ganciclovir, acyclovir and ribavirin, are invalid for 2019-nCoV and not recommended. Drugs are possibly effective for 2019-nCoV include: remdesivir, lopinavir/ritonavir, lopinavir/ritonavir combined with interferon-β, convalescent plasma, and monoclonal antibodies. But the efficacy and safety of these drugs for 2019-nCoV pneumonia patients need to be assessed by further clinical trials.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, H" sort="Li, H" uniqKey="Li H" first="H" last="Li">H. Li</name></noRegion><name sortKey="Cao, B" sort="Cao, B" uniqKey="Cao B" first="B" last="Cao">B. Cao</name><name sortKey="Wang, Y M" sort="Wang, Y M" uniqKey="Wang Y" first="Y M" last="Wang">Y M Wang</name><name sortKey="Xu, J Y" sort="Xu, J Y" uniqKey="Xu J" first="J Y" last="Xu">J Y Xu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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